Imovane innehåller den aktiva substansen zopiklon som påverkar de centra i hjärnan som gör att vi kan sova och har vanligen effekt inom 30 minuter.
Zopiclone, sold underneath the model title Imovane among Other people, is usually a nonbenzodiazepine, specially a cyclopyrrolone, utilised to take care of issues sleeping. Zopiclone is molecularly distinct from benzodiazepine medications and is classed for a cyclopyrrolone.
Det är dock viktigt att notera att detta kan vara olagligt och farligt, eftersom det kan leda until biverkningar och interaktioner med andra läkemedel.
Zopiclone is inside the cyclopyrrolone spouse and children of medication. Other cyclopyrrolone medications involve suriclone. Zopiclone, Even though molecularly various from benzodiazepines, shares an Virtually identical pharmacological profile as benzodiazepines, which includes anxiolytic Homes. Its mechanism of motion is by binding to your benzodiazepine web-site and acting as a full agonist, which subsequently positively modulates benzodiazepine-delicate GABAA receptors and enhances GABA binding in the GABAA receptors to produce zopiclone's pharmacological Houses.
The pharmacokinetics of zopiclone are altered by aging and are influenced by renal and hepatic capabilities.[sixty nine] In significant Long-term kidney failure, the world under the curve value for zopiclone was larger and also the 50 %-everyday living affiliated with the elimination fee continuous longer, but these improvements were not thought of as clinically considerable.[70] Intercourse and race haven't been found to communicate with pharmacokinetics of zopiclone.[two]
W okresie stosowania preparatu nie należy spożywać alkoholu ani przyjmować substancji psychoaktywnych czy innych leków działających na ośrodkowy układ nerwowy, ponieważ zwiększają just one ryzyko wystąpienia wymienionych powyżej zaburzeń.
Zopiclone is usually a sedative. It really works by creating a depression or tranquilization from the central nervous program. Soon after prolonged use, the body can become accustomed to the consequences of zopiclone. In the event the dose is then lessened or perhaps the drug is abruptly stopped, withdrawal symptoms may result. These can contain An array of indications comparable to All those of benzodiazepine withdrawal.
Bardzo rzadko: zwiększenie aktywności enzymów wątrobowych oraz fosfatazy alkalicznej, reakcje nadwrażliwości, w tym obrzęk naczynioruchowy i reakcje anafilaktyczne.
An intensive evaluation of your health care literature concerning the administration of sleeplessness as well as the elderly uncovered that substantial evidence in the performance and Long lasting great things about nondrug treatments for sleeplessness exist. As opposed Using the benzodiazepines, the nonbenzodiazepine sedative-hypnotics, including zopiclone, provide couple of if any pros in efficacy or tolerability in elderly folks. Newer brokers such as the melatonin receptor agonists may be extra ideal and efficient for that management of Continual sleeplessness in aged people.
Zopiclone together with other sedative hypnotic medication are detected commonly in circumstances of folks suspected of driving under the impact of medications. Other sedating prescription drugs, which includes benzodiazepines and zolpidem, also are located in high numbers of suspected drugged drivers. Several drivers have blood amounts much exceeding the therapeutic dose array and sometimes in combination with alcohol, unlawful, or addictive prescription medicines, suggesting a large degree of opportunity for non-medical use of benzodiazepines, zolpidem, and zopiclone.
Інформація для людей з України, що шукають порятунку від війни в Україні
Patients with liver illness eradicate zopiclone considerably more slowly than typical sufferers and Moreover knowledge exaggerated pharmacological results of the drug.[18]
Aby zminimalizować ryzyko, zaleca się zachowanie co najmniej twelve godzinnego odstępu pomiędzy przyjęciem preparatu a prowadzeniem pojazdu, obsługiwaniem maszyn czy wykonywaniem innych czynności wymagających koncentracji i sprawności psychoruchowej (np. praca more info na wysokości).
Rifampicin triggers an exceedingly notable reduction in fifty percent-life of zopiclone and peak plasma degrees, which leads to a sizable reduction while in the hypnotic influence of zopiclone. Phenytoin and carbamazepine may also provoke comparable interactions.
Nasileniu bezsenności mogą towarzyszyć inne objawy, takie jak zmiany nastroju, niepokój, pobudzenie i nasilony lęk. Ryzyko wystąpienia tych objawów jest większe po nagłym przerwaniu stosowania preparatu i dlatego zaleca się najpierw stopniowe zmniejszanie dawki.